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Season
- The Tonight Show with Jay Leno Season 0 2014-02-06
- The Tonight Show with Jay Leno Season 1 1992-05-25
- The Tonight Show with Jay Leno Season 2 1993-06-25
- The Tonight Show with Jay Leno Season 3 1994-11-28
- The Tonight Show with Jay Leno Season 4 1996-03-07
- The Tonight Show with Jay Leno Season 5 1996-09-16
- The Tonight Show with Jay Leno Season 6 1997-12-05
- The Tonight Show with Jay Leno Season 7 1998-02-26
- The Tonight Show with Jay Leno Season 8 1999-07-30
- The Tonight Show with Jay Leno Season 9 2000-08-01
- The Tonight Show with Jay Leno Season 10 2002-04-30
- The Tonight Show with Jay Leno Season 11 2002-06-03
- The Tonight Show with Jay Leno Season 12 2003-06-02
- The Tonight Show with Jay Leno Season 13 2004-06-07
- The Tonight Show with Jay Leno Season 14 2005-06-06
- The Tonight Show with Jay Leno Season 15 2006-09-18
- The Tonight Show with Jay Leno Season 16 2007-09-17
- The Tonight Show with Jay Leno Season 17 2008-06-02
- The Tonight Show with Jay Leno Season 18 2010-03-01
- The Tonight Show with Jay Leno Season 19 2011-01-03
- The Tonight Show with Jay Leno Season 20 2012-01-03
- The Tonight Show with Jay Leno Season 21 2013-01-02
Episode
- Episode 1 : Howie Mandel, Amanda Bynes, Emmylou Harris
- Episode 2 : Jamie Foxx, Tim Gunn, Paolo Nutini
- Episode 3 : Dane Cook, Ali Larter, LCD Soundsystem
- Episode 4 : Jessica Alba, D.L. Hughley, Cold War Kids
- Episode 5 : Hugh Laurie, Sherri Shepherd, The Editors
- Episode 6 : Dwayne "The Rock" Johnson, Dennis Kucinich, Diana Krall
- Episode 7 : Jennifer Love Hewitt, Jeff Corwin, Reba McEntire with Vince Gill
- Episode 8 : Steve Carell, Madison Pettis, Bright Eyes
- Episode 9 : Ben Stiller, Tony Snow, Raul Midon
- Episode 10 : Teri Hatcher, Kevin McKidd, Queen Latifah
- Episode 11 : Patricia Heaton, Emeril Lagasse, Tori Amos
- Episode 13 : Tom Selleck, Carlos Mencia, Bobbie and Willie Nelson
- Episode 14 : John Larroquette, Chelsea Handler, Matchbox Twenty
- Episode 15 : Cate Blanchett, Tyler Perry, Annie Lennox
- Episode 16 : Ben Affleck, Jim Norton, The Shins
- Episode 17 : Jaime Pressly, Brady Barr, Blue Man Group
- Episode 18 : Dana Carvey, Malin Akerman, Plain White T's
- Episode 19 : Joaquin Phoenix, Gordon Ramsay, Vanessa Carlton
- Episode 20 : Christina Applegate, Bill O'Reilly, Alicia Keys
- Episode 21 : James Spader, Lara Logan, Steve Byrne
- Episode 22 : Reese Witherspoon, David Koechner, PJ Harvey
- Episode 23 : Sen. Barack Obama, Orny Adams, Keith Urban
- Episode 24 : Jerry Seinfeld, Amy Ryan, Evanescence
- Episode 25 : Halle Berry, Greg Grunberg, Dwight Yoakam
- Episode 26 : Russell Crowe, Jenna Bush, Carrie Underwood
- Episode 27 : Tom Cruise, Rep. Ron Paul, Sex Pistols
- Episode 28 : Eva Mendes, Marjorie Johnson, Barry Manilow
- Episode 29 : Denzel Washington, Dave Salmoni, LeAnn Rimes
- Episode 30 : Steve Carell, Manny Ramirez, Backstreet Boys
- Episode 31 : Gov. Mike Huckabee, Emeril Lagasse, Chingy
- Episode 32 : Howie Mandel, Jason Lewis, Joe Nichols
- Episode 33 : Animals With Jarod Miller, John Caparulo, Blake Lewis
- Episode 34 : Ron Paul, Christopher Titus, Shakira
- Episode 35 : Pamela Anderson, Mary J. Blige
- Episode 36 : Jules Sylvester and animals, Maria Bartiromo, Finger Eleven
- Episode 37 : Jimmy Kimmel, Elon Gold, OneRepublic
- Episode 38 : Arsenio Hall, Melanie Metz & Peggy Willenberg, Seether
- Episode 39 : Marilu Henner, Brady Barr, Jordan Sparks
- Episode 40 : Bill Maher, Carrie Ann Inaba & Bruno Tonioli, Taylor Swift
- Episode 41 : Chris Matthews, John Roy, Jill Scott
- Episode 42 : D.L. Hughley, Joe Ligotti, Sara Bareilles
- Episode 43 : Mitt Romney, Ryan Sheckler, Jonas Brothers
- Episode 44 : Simon Cowell & Ryan Seacrest, Tavis Smiley, Shaggy
- Episode 45 : David Gregory, Performing Birds, Puddle Of Mudd
- Episode 46 : Adam Carolla, Richard Roeper, Shooter Jennings
- Episode 47 : Animals With Julie Scardina, Chelsea Handler, Buckcherry
- Episode 48 : Hulk Hogan, Mad Scientist David Willey, Natasha Bedingfield
- Episode 49 : Chazz Palminteri, Alison Sweeney, Dierks Bentley
- Episode 50 : Lester Holt, Blue Ribbon Baker Marjorie Johnson, Raheem DeVaughn
- Episode 51 : Animals with Dave Salmoni, Tom Green, Maroon 5
- Episode 52 : Sen. John McCain, Rudy Giuliani, Shelby Lynne
- Episode 53 : Tom Brokaw, Terrell Owens, Graham Colton
- Episode 54 : Dan Rather, Mike Rowe, Josh Kelley
- Episode 55 : Insects with Brent Karner, Stephen Baldwin, J. Holiday
- Episode 56 : Frank Caliendo, Chimp Rescuer Eugene Cussons, Flo Rida
- Episode 57 : Arsenio Hall, Paula Deen, James Blunt
- Episode 58 : Brian Williams, Ahmed Ahmed, Enrique Iglesias
- Episode 59 : Larry the Cable Guy, Bobby Knight, Andrea Bocelli
- Episode 60 : Larry the Cable Guy, Bruno Tonioli, Glen Hansard & Markéta Irglová
- Episode 61 : Joan Embery and Animals, Larry the Cable Guy, Mika
- Episode 62 : Russell Crowe, Larry the Cable Guy, Willie Nelson
- Episode 63 : Kristen Chenoweth, Russell Peters, Lifehouse
- Episode 64 : Reese Witherspoon, Alex Cambert, Gary Allan
- Episode 65 : Will Ferrell, Hayden Christensen, The Hives
- Episode 66 : Garth Brooks, Christina Ricci
- Episode 67 : Heidi Klum, James McAvoy, John Fogerty
- Episode 68 : Colin Farrell, Bill O'Reilly, Herbie Hancock
- Episode 69 : Eric Bana, Catherine O'Hara, Tift Merritt
- Episode 70 : Dennis Quaid, David Koechner, Lupe Fiasco
- Episode 71 : Billy Ray Cyrus, Miley Cyrus, Brooke Shields
- Episode 72 : Wanda Sykes, Bryan Cranston, Cat Power
- Episode 73 : Dave Salmoni and Animals, Patricia Arquette, The Punch Brothers
- Episode 74 : Dominic Monaghan, Ethan Bortnick, Sheryl Crow
- Episode 75 : America Ferrera, Bob Saget, The Blind Boys of Alabama
- Episode 76 : Bill Cosby, Novak Djokovic, Landon Pigg
- Episode 77 : Howie Mandel, Minnie Driver
- Episode 78 : Gordon Ramsay
- Episode 79 : Kate Beckinsale, Carlos Mencia, The Bravery
- Episode 80 : Terry Bradshaw, James Carville & Mary Matalin, Michael McDonald
- Episode 81 : Ryan Phillippe, Lisa Lampanelli, Jim Lauderdale
- Episode 82 : John Edwards, Leslie Mann, Nada Surf
- Episode 83 : Adam Carolla, Geraldo Rivera, The Black Crowes
- Episode 84 : Peter O'Toole, Katt Williams, Leona Lewis
- Episode 85 : Abigail Breslin, Seth Meyers, Steve Earle
- Episode 86 : John Krasinski, Joe Torre, José González
- Episode 87 : Conan O'Brien, Anderson Cooper, Allison Moorer
- Episode 88 : John Larroquette, Kid Inventors, k.d. lang
- Episode 89 : Jodie Foster, Cedric the Entertainer, Lili Haydn
- Episode 90 : Mike Huckabee; Emeril Lagasse; Chingy
- Episode 91 : Steve Carell, Kathie Lee Gifford, Ani DiFranco
- Episode 92 : Sen. Hillary Clinton, Patton Oswalt, Ferras
- Episode 93 : David Spade, Nora Hardwick, Ben Lee
- Episode 94 : Pamela Anderson; Mary J. Blige
- Episode 95 : Jules Sylvester; Maria Bartiromo; Finger Eleven
- Episode 96 : Jimmy Kimme; Elon Gold; OneRepublic
- Episode 97 : Keanu Reeves, Chelsea Handler, The Redwalls
- Episode 98 : William Shatner, Tricia Helfer, Ryan Bingham
- Episode 99 : Mark Harmon, Corbin Maxey, Ray J
- Episode 100 : Brad Garret; Ingrid Michaelson; John Melendez
- Episode 101 : Charles Barkley, The Young@Heart Chorus
- Episode 102 : Ewan McGregor, John Cho & Kal Penn, Seether
- Episode 103 : Tracey Ullman, Jason Taylor, Flogging Molly
- Episode 104 : Dave Salmoni, Norm MacDonald, Ashlee Simpson
- Episode 105 : Julia Louis-Dreyfus, Jason Segel, Goldfrapp
- Episode 106 : Patrick Dempsey, Ed Begley Jr., Tegan and Sara
- Episode 107 : Gov. Arnold Schwarzenegger, Marilu Henner, Old 97's
- Episode 108 : Hugh Laurie, Doug Fine, Prince
- Episode 109 : Helen Hunt, Gov. Bobby Jindal, Duffy
- Episode 110 : Dr. Phil McGraw, the Lopez family, Natasha Bedingfield
- Episode 111 : Cindy McCain, Ed Helms, Augustana
- Episode 112 : Robin Williams, Terrence Howard, Serj Tankian
- Episode 113 : Sally Field, Jesse Ventura, Sleepercar
- Episode 114 : Robert Downey Jr., Carlos Mencia, Rascal Flatts
- Episode 115 : Julie Scardina and animals, Christina Ricci, KT Tunstall
- Episode 116 : Former President Jimmy Carter, Jon Favreau, P.O.D.
- Episode 117 : Jenna Fischer, Robert Schimmel, Trace Adkins
- Episode 118 : Harrison Ford, William Moseley, Carly Simon
- Episode 119 : Jack Black, Clay Aiken
- Episode 120 : Evangeline Lilly, Ben Barnes, Switchfoot
- Episode 121 : Rainn Wilson, Howard Dean, Kate Nash
- Episode 122 : Dana Delany, Adam Carolla, Dwight Yoakam
- Episode 123 : Matthew Fox, Kathleen Edwards
- Episode 124 : Simon Cowell, Rob Schneider, Josh Groban
- Episode 125 : Sylvester Stallone, Irma & Ray Ziff, Jason Mraz
- Episode 126 : Adam Sandler, Hilary Duff, Al Green
- Episode 127 : Laura & Jenna Bush, David Cook, Tristan Prettyman
- Episode 128 : Terry Bradshaw, Turkey Baster Virtuoso Ray Sanders, Colbie Caillat
- Episode 129 : William Shatner, Chelsea Handler, Newton Faulkner
- Episode 130 : Liv Tyler, Judd Apatow, Usher
- Episode 131 : Jeff Foxworthy, Arianna Huffington, N.E.R.D.
- Episode 132 : Dave salmoni; Patricia Arquette; Punch Brothers
- Episode 133 : Will Smith, Pete Sampras, Ed Harcourt
- Episode 134 : Russel Brand, Bill Engvall, Aimee Mann
- Episode 135 : Justin Timberlake, Karen Allen, Sheryl Crow
- Episode 136 : Dana Carvey, Spencer Breslin, Priscilla Ahn
- Episode 137 : Mike Myers, Abigail Breslin, David Cook
- Episode 138 : Larry the Cable Guy, Bob Costas, Ashanti
- Episode 139 : Anne Hathaway; Gabriel Iglesias; Amos Lee
- Episode 140 : Ryan Phillippe; Lisa Lampanelli; Jim Lauderdale
- Episode 141 : Dwayne "The Rock" Johnson, Tom Papa, Against Me!
- Episode 142 : Wanda Sykes, James McAvoy, Duffy
- Episode 143 : Bette Midler, Al Roker
- Episode 144 : Selma Blair, Kevin Nealon, Steve Tyrell
- Episode 145 : Aaron Eckhart, Dara Torres, Los Lonely Boys
- Episode 146 : Animal Expert Jarod Miller, David Koechner, Sara Bareilles
- Episode 147 : Conan O'Brien; Anderson Cooper; Allison Moorer
- Episode 148 : John Larroquette; Kid Inventors; K.D. Lang
- Episode 149 : Jodie Foster; Cedric the Entertainer; Lili Hayden
- Episode 150 : David Beckham; Sherri Shepherd; B-52s
- Episode 151 : Steve Carell; Kathie Lee Gifford; Ani LiFranco
- Episode 152 : Hillary Clinton; Patto Oswalt; Ferras
- Episode 153 : David Spade; Nora Hardwick; Ben Lee
- Episode 154 : Thomas Haden Church; Sig & Edgar Hansen; Jimmy Eat World
- Episode 155 : Dennis Quaid; Russell Brand; Brett Dennen
- Episode 156 : Ellen Page; Donny & Marie Osmond; Angie Stone
- Episode 157 : Keanu Reeves; Chelsea Handler; The Redwalls
- Episode 158 : William Shatner; Tricia Helfer; Ryan Bingham
- Episode 159 : Mark Harmon; Corbin Maxey; Ray J
- Episode 160 : Brad Garrett; John Melendez; Ingrid Michaelson
- Episode 161 : Charles Barkley; Young @ Heart Chorus
- Episode 162 : Rosie Perez, Robin Thicke
- Episode 163 : Bill Cosby, Emma Stone, John Mellencamp with T Bone Burnett
- Episode 164 : Ben Stiller, Jonas Brothers
- Episode 165 : Robert Downey Jr., Anna Faris, Toby Keith
- Episode 166 : Jack Black, Pillsbury Bake-Off-Champ Carolyn Gurtz, Conor Oberst
- Episode 167 : Nick Nolte, Carrot Top, Solomon Burke
- Episode 168 : Hugh Laurie; Doug Fine; Prince
- Episode 169 : Sen. John McCain, Dara Torres, Juliana Hatfield
- Episode 170 : Norm MacDonald, Nastia Liukin, B.B. King
- Episode 171 : Bill Maher, Henry Cejudo, Low vs Diamond
- Episode 172 : Gordon Ramsay, Natalie Coughlin, Missy Higgins
- Episode 173 : Arsenio Hall, Shawn Johnson, Chuck Berry
- Episode 174 : Russell Brand, Eva Longoria Parker, Ingrid Michaelson
- Episode 175 : Billy Bob Thornton, Ethan Bortnick, Brian Wilson
- Episode 176 : Howie Mandel, Sanya Richards, The Game
- Episode 177 : Jenna Fischer; Robert Schimmel; Trace Adkins
- Episode 178 : Harrison Ford; William Moseley; Carly Simon
- Episode 179 : Jules Sylvester, Annette Bening, Leona Lewis
- Episode 180 : Matthew McConaughey, T. Boone Pickens, Al Green
- Episode 181 : Jamie Lee Curtis, Jerome Bettis, Alejandro Escovedo
- Episode 182 : Hugh Laurie, Dame Edna, Raphael Saadiq
- Episode 183 : Matthew Fox; Kathleen Edwards
- Episode 184 : Simon Cowell; Rob Schneider; Josh Groban
- Episode 185 : Sylvester Stallone; Irma & Ray Ziff; Jason Mraz
- Episode 186 : Adam Sandler; Hillary Duff; Al Green
- Episode 187 : Laura & Jenna Bush; David Cook; Tristan Prettyman
- Episode 188 : Terry Bradshaw; Ray Sanders; Colbie Caillat
- Episode 194 : Ellen Degeneres; Jerry O'Connell; Jazmine Sullivan
The Tonight Show with Jay Leno - Season 16 Episode 152
